myIIT
| 1 | Title of the course (L-T-P-C) | Biomolecules (2-1-0-6) |
| 2 | Pre-requisite courses(s) | - |
| 3 | Course content | Major classes of biological molecules: Comparison of the alphabets and sources of structural diversity of proteins, nucleic acids, carbohydrates and lipids. Proteins : Ramachandran plot, evolution of protein structure, structure-function relationships: myoglobin and adaptions in myoglobin structure in deep diving mammals; allostery in hemoglobin; Bohr effect (for pH and carbon dioxide); adult and foetal hemoglobin. Post-translational modifications: special types of covalent bonds found in proteins. Protein folding: Natively folded and natively disordered proteins; miniproteins and peptine toxins; Anfinsen's observations, Levinthal paradox, cooperatively in protein folding; free energy landscape of protein folding and pathways of protein folding, molten globule state, diseases associated with protein folding. Carbohydrates: Sources of structural diversity; structure-function relationship in glycogen and celllose, Difficulty associated with sequencing of glycans. Lipids : Structure and properties of storage and membrane lipids. Self-assembly of lipids:packing parameter; Biomembrane organization-sidedness and function; membrane bound proteins - structure, properties and function; transport phenomena. Nucleic acids : Historical perspective leading up to the proposition of DNA double helical structure of RNA; chromatin organization. Enzymes: General principles of catalysis; quantitation of enzyme activity and efficiency; Henri-Michaelis-Menten and Briggs-Haldane relationships; Transition state: definition Pauling's intuition and proposal, catalytic antibodies; Catalytic strategies; Isozymes : Haldane relationship between kinetic constants and equilibrium constant; Zymogens. Bioenergetics: basic principles; equilibria and concept of free energy; coupled interconnecting reactions in metabolism; oxidation of carbon fuels; recurring motifs in metabolism. Relevant metabolic pathways may be included to discuss relevant concepts. |
| 4 | Texts/References |
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